Effects of Oren-gedoku-to and its constituents on the cardiovascular system: Investigation of its efficacy in hotflush.
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Accession number;03A0126866
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| Title;Effects of Oren-gedoku-to and its constituents on the cardiovascular system: Investigation of its efficacy in hotflush. |
| Author;
WAKITA HIROMI
(Tsumura Kaihatsuhombu)
MIYAMOTO KEN'ICHI
(Kanazawa Univ., Hospital, JPN)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.6;PAGE.230-237(2002)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The auricular blood flow in intact rats decreased maximally at 15min after administration of Oren-gedoku-to extract (1.0g/kg, intraduodenal (i.d.)), although the heart rates and the blood pressure scarcely changed. In rats pretreated intravenously with theophylline (5mg/kg), the auricular blood flow also decreased similarly after its administration, while the heart rate and the blood pressure decreased. The extract (0.35g/kg, i.d.) of Scutellariae Radix which is the main constituent of Oren-gedoku-to decreased the auricular blood flow, the heart rate, and the blood pressure. On the other hand, In rats pretreated with reserpine (5mg/kg, i.v.) 24hrs before the administration, the blood flow, heart rate and blood pressure were not hardly affected after administration of both Oren-gedoku-to and Scutellariae Radix. In the isolated right and left atria, and papillary muscle of rats, the frequency and the strength of contraction was not influenced with Oren-gedoku-to extract and its constituent plant extracts. In the isolated Langendorff's heart of rats, the left ventricular systolic maximum pressure and heart rate were not influenced with Oren-gedoku-to, although the coronary flow was slightly increased. The above results suggest that Oren-gedoku-to is useful in fotflush, because of its decreasing effects on auricular blood flow without cardiac function, and among the constituent plants of Oren-gedoku-to, Scutellariae Radix plays a main part. (author abst.) |
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