Science Links Japan | Disposition of Morphine after Oral Administration of Morphine Hydrochloride Tablets and Solution in Preoperative Cancer Patients.

Disposition of Morphine after Oral Administration of Morphine Hydrochloride Tablets and Solution in Preoperative Cancer Patients.

Accession number;03A0109471

Title;Disposition of Morphine after Oral Administration of Morphine Hydrochloride Tablets and Solution in Preoperative Cancer Patients.

Author; MIZUGUCHI TADANOBU (San'obyoin Kanwakeaka)

Journal Title;Clinical Pharmacology and Therapy

Journal Code:L1701A

ISSN:0917-3994

VOL.13;NO.1;PAGE.15-24(2003)

Figure&Table&Reference;FIG.2, TBL.2, REF.21

Pub. Country;Japan

Language;Japanese

Abstract;Disposition of morphine after oral administration of morphine hydrochloride tablets and solution to preoperative patients with cancer was investigated and following results were obtained. 1) Although morphine from tablets showed somewhat delayed absorption behavior compared with solution, no significant difference in the plasma concentration at any time was observed. There was also no significant difference in the areas under the plasma concentration-time curve (AUC) between tablets and solution. 2) There was no difference in the plasma concentration-time curve of morphine metabolites, morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G), between tablets and solution. Maximum plasma concentrations (Cmax) of M-3-G and M-6-G were 9.6-52.0 and 2.2-10.7 folds higher than that of morphine, respectively. The molar ratio between AUC for M-3-G and morphine was the range of 8.6 to 28.0. In the case of M-6-G, the corresponding value was the range of 1.8 to 5.0. These results indicate that morphine is remarkably metabolized to M-3-G and M-6-G with large intersubject variation when orally received, although there is no essential difference in the bioavailability between tablets and solution. (author abst.)

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