Quantitative Trait Locus Analysis of Serum Insulin, Triglyceride, Total Cholesterol and Phospholipid Levels in the (SM/J*A/J)F2 Mice.
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Accession number;03A0132762
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| Title;Quantitative Trait Locus Analysis of Serum Insulin, Triglyceride, Total Cholesterol and Phospholipid Levels in the (SM/J*A/J)F2 Mice. |
| Author;
ANUNCIADO R V P
(Nagoya Univ., Nagoya, Jpn)
NISHIMURA M
(Nagoya Univ. School Of Medicine, Nagoya, Jpn)
MORI M
(Shinshu Univ. School Of Medicine, Matsumoto, Jpn)
ISHIKAWA A
(Nagoya Univ., Nagoya, Jpn)
TANAKA S
(National Chubu Hospital, Aichi, Jpn)
HORIO F
(Graduate School Of Bioagricultural Sci., Nagoya, Jpn)
OHNO T
(Nagoya Univ. School Of Medicine, Nagoya, Jpn)
NAMIKAWA T
(Nagoya Univ., Nagoya, Jpn)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.52;NO.1;PAGE.37-42(2003)
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| Figure&Table&Reference;TBL.4, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Quantitative trait locus(QTL) analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels at 10 weeks of age was performed in 321 F2 offspring from SM/J and A/J mice. Interval mapping revealed a total of 22 suggestive QTLs affecting the four traits: two insulin QTLs on Chromosomes(Chrs) 6 and 8; six triglyceride QTLs on Chrs 4,8,9,11,12 and 19; six total-cholesterol QTLs on Chrs 1,3,4,14,17 and 19; and eight phospholipid QTLs on Chrs 2,3,4,6,8,10 and 19. Gender influenced the expression of eight of the suggestive QTLs. The total-cholesterol QTLs on Chrs 4,14 and 17, the triglyceride QTL on Chr 9 and the phospholipid QTL on Chr 4 were specific to females. The phospholipid QTLs on Chrs 2 and 6 and the insulin QTL on Chr 8 were specific to males. In addition, common QTLs involved in the regulation of some of the traits were identified. The female-specific QTL on Chr 4 appeared to be involved in the regulation of total cholesterol and phospholipid levels. The QTL on Chr 8 affected insulin and phospholipid levels, whereas the Chr 19 QTL was common to the three lipid parameters. (author abst.) |
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