Practical Treatment with Minimum Maintenance Dose of Anti-Thyroid Drugs for Prediction of Remission in Graves' Disease.
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Accession number;03A0147507
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| Title;Practical Treatment with Minimum Maintenance Dose of Anti-Thyroid Drugs for Prediction of Remission in Graves' Disease. |
| Author;
KASHIWAI T
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
HIDAKA Y
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
TAKANO T
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
TATSUMI K
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
IZUMI Y
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
SHIMAOKA Y
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
TADA H
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
TAKEOKA K
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
AMINO N
(Osaka Univ. Graduate School Of Medicine, Osaka, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.50;NO.1;PAGE.45-49(2003)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Although many reserchers have reported clinical and laboratory parameters for prediction of remission in Graves' disease during or after anti-thyroid drug therapy, there is no reliable one to assure the complete remission. We prospectively examined a practical therapy with minimum maintenance dose of anti-thyroid drugs for prediction of remission in Graves' disease Fifty-seven patients with Graves' disease were treated with anti-thyroid drugs at the initial dose of 30mg/day of methimazole(MMI) or 300mg/day of propylthiouracil(PTU). Then, doses were gradually decreased, and finally discontinued when the patients were able to maintain euthyroid(normal FT4 and TSH) for at least 6 months with the minimum maintenance dose(MMI 5mg every other day or PTU 50mg every other day). After discontinuation of drugs, FT4, FT3, TSH and TSH-binding inhibitory immunoglobulin(TBII) were measured every one to two months for the first 6 months and every 3-4 months for the next 18 months to confirm continuous remission. After 2 years of drug cessation, 46(81%) of 57 patients were in remission and the other 11 patients had relapsed into thyrotoxicosis. At the time of drug discontinuation, the serum concentration of FT4, FT3 and TSH, titers of anti-thyrolobulin antibodies and anti-thyroid microsomal antibodies, goiter size were not different between the remission and relapse groups. At the time of drug cessation, the activities of TBII and thyroid-stimulating antibodies(TSAb) overlapped between the two groups, although they were significantly lower in the remission group than in the relapse group(p<0.01).... (author abst.) |
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