New theory on gene regulation: Mechanism of formation of chromosome functional and boundary regions.
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Accession number;03A0148972
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| Title;New theory on gene regulation: Mechanism of formation of chromosome functional and boundary regions. |
| Author;
HORIKOSHI MASAMI
(Inst. Molecular and Cellular Biosci., Univ. of Tokyo)
YAMAMOTO TOORU
(Inst. Molecular and Cellular Biosci., Univ. of Tokyo)
UMEHARA TAKASHI
(Inst. Molecular and Cellular Biosci., Univ. of Tokyo)
SUZUKI TOORU
(Inst. Molecular and Cellular Biosci., Univ. of Tokyo)
ADACHI NARUHIKO
(Inst. Molecular and Cellular Biosci., Univ. of Tokyo)
KIMURA AKATSUKI
(Inst. Molecular and Cellular Biosci., Univ. of Tokyo)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.3;PAGE.205-222(2003)
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| Figure&Table&Reference;FIG.11, TBL.1, REF.46 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Authors consider how to exceed Jacob-Monod's operon theory, and conclude that it is essential to construct new theory on regulatory mechanisms of gene expression from histone-bound conditions that are completely changed genetic DNA states. And, they have sought its solution in mechanism of formation of chromosome functional and boudary regions as a contrivance to explain the regulatory mechanisms of gene expression in eucaryotes, of which gene numbers have been increased. As the results of analyses, authors have succeeded in establishing a novel theory on gene expression regulation, which proposes the formation of chromosome functional region by two different enzymes, and of negotiable boundary region through formation of acetylation gradient by both attacks. |
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