Elevated High-sensitivity C-reactive Protein Correlates with Insulin Resistance and Hyper-E-selectinemia in Patients with Type 2 Diabetes.
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Accession number;03A0149367
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| Title;Elevated High-sensitivity C-reactive Protein Correlates with Insulin Resistance and Hyper-E-selectinemia in Patients with Type 2 Diabetes. |
| Author;
MATSUMOTO KAZUNARI
(Sasebochuobyoin Tonyobyotaishanaika)
SERA YASUNORI
(Sasebochuobyoin Tonyobyotaishanaika)
ABE YASUYO
(Sasebochuobyoin Naibumpika)
TOMINAGA TAN
(Sasebochuobyoin Naibumpika)
MIYAKE SEIBEI
(Sasebochuobyoin Tonyobyotaishanaika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.46;NO.1;PAGE.1-5(2003)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.28 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;High-sensitivity C-reactive protein (hs-CRP) was recently identified as an independent predictor of atherosclerotic vascular disease. The physiological significance of elevated hs-CRP remains to be evaluated, however. To determine the relationship between hs-CRP and insulin resistance and serum E-selectin, an endothelial activation marker, we conducted a case-control study of 45 diabetic patients with high hs-CRP (.GEQ.0.10 mg/dl) and 45 age- and gender-matched diabetic patients with low hs-CRP (.LEQ.0.03 mg/dl). Patients with high hs-CRP had a significantly greater body mass index and triglycerides, and significantly lower HDL cholesterol. Insulin sensitivity, measured by the K index of the insulin tolerance test (Kitt), was significantly lower in patients with high hs-CRP than in those with low hs-CRP (2.29.+-.0.88 vs. 2.82.+-.1.11 %/min, mean.+-.SD, p<0.05). The mean soluble adhesion molecule, E-selectin, was significantly higher in patients with high hs-CRP than in those with low hs-CRP(70.9.+-.29.8 vs. 55.4.+-.30.8 ng/ml, p<0.01). Our results indicate that elevated hs-CRP in patients with type 2 diabetes reflect the presence of insulin resistance and endothelial activation. (author abst.) |
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