Hyperglycemia Associated with IL-6 Producing Renal Cell Carcinoma.

Accession number;03A0149370
Title;Hyperglycemia Associated with IL-6 Producing Renal Cell Carcinoma.
Author; TSUKAMOTO KAZUHISA (Univ. of Tokyo, Univ. Hosp.) MORISAWA YUJI (Univ. of Tokyo, Fac. of Med.) FUKAYAMA MASASHI (Univ. of Tokyo, Fac. of Med.) OKADA TERUMASA (Univ. of Tokyo, Univ. Hosp.) KONO MASASHI (Univ. of Tokyo, Fac. of Med.) ASANO TOMOICHIRO (Univ. of Tokyo, Univ. Hosp.) SHIBASAKI YOSHIKAZU (Univ. of Tokyo, Univ. Hosp.) KADOWAKI TAKASHI (Univ. of Tokyo, Univ. Hosp.) KIMURA SATOSHI (Univ. of Tokyo, Univ. Hosp.)
Journal Title;Journal of the Japan Diabetic Society
Journal Code:Z0279B
ISSN:0021-437X
VOL.46;NO.1;PAGE.15-22(2003)
Figure&Table&Reference;FIG.5, TBL.2, REF.27
Pub. Country;Japan
Language;Japanese
Abstract;A 59-year-old male with a 2-year history of diabetes mellitus and a half-year history of hematuria, night sweats, and back pain was admitted for glycemic control and to evaluate bilateral renal tumors. Laboratory data showed rising inflammatory markers and increased HbA1C of 7.9%. Glycemic control required 37 units of insulin daily preoperatively for the renal tumors, but no medication was required for glycemic control postoperatively. Preoperative plasma interleukin (IL)-6 was 21.2 pg/ml and a histological evaluation confirmed IL-6 expression by some of the renal cell carcinomas. Six months later, when glycemic control was satisfactory and plasma IL-6 was normal, a metastatic lesion was noted in the lung and excised. Histological examination showed no IL-6 expression in this metastatic lesion. One year later, however, further lung metastasis was found and glycemic control worsened gradually accompanied by increasing plasma IL-6 along with the expansion and dissemination of lung metastasis. This is, to our knowledge, the first case report demonstrating the possible association of glycemic control and IL-6 production by the tumor cells in renal cell carcinoma. (author abst.)
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