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Accession number;03A0200518
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| Title;Effect of Iron Deficiency on the Hepatic Glutathione Content and Glutathione S-Transferase Activity in Female Rats. |
| Author;
SHIMIZU MASATOMI
(Otsuma Women's Univ. Fac. of Home Econ.)
IWAMA MASAHIKO
(Tokyo Univ. Agriculture, Dep. Applied Biology and Chemistry, JPN)
KANKE YUSUKE
(Otsuma Women's Univ. Fac. of Home Econ.)
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Journal Title;Journal of Home Economics of Japan
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Journal Code:F0763A
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ISSN:0913-5227
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VOL.54;NO.3;PAGE.209-212(2003)
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| Figure&Table&Reference;TBL.1, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The purpose of this study was to investigate the effect of an iron-deficient diet on the hepatic glutathione (GSH) level, glutathione S-transferase (GST) activity and cytochrome P-450 (P-450) content in young female rats. Wistar-strain female rats (40-50 g in body wt.) were fed ad libitum with a normal diet (50 ppm Fe) or iron-deficient diet (8 ppm Fe) diet for 4 weeks. Compared to the control rats given the normal diet lower feed intake, weight gain, liver weight and hemoglobin concentration were found in those fed on the iron-deficient diet. In respect of the hepatic drug-metabolizing system, an increase in GSH level was observed together with the induction of P-450 content in the iron-deficient animals. The GST activity against three different substrates (1-chloro-2,4-dinitrobenzene, 3,4-dichloronitrobenzene and trans-4-phenyl-3-buten-2-one) was also higher in the iron-deficient rats. The data suggest that iron-deficient young female animals may respond differently to drugs and chemicals than their non-iron-deficient counterparts. (author abst.) |
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