Science Links Japan | Antitumor Effect of Extracts Obtained from Fruiting Body of Agaricus blazei Murill. Comparison with Extracts Obtained from Mycelium of Coriolus, PSK.

Antitumor Effect of Extracts Obtained from Fruiting Body of Agaricus blazei Murill. Comparison with Extracts Obtained from Mycelium of Coriolus, PSK.

Accession number;03A0136114

Title;Antitumor Effect of Extracts Obtained from Fruiting Body of Agaricus blazei Murill. Comparison with Extracts Obtained from Mycelium of Coriolus, PSK.

Author; EBINA TAKUSABURO (Miyagi Cancer Center, Res. Inst., JPN)

Journal Title;Biotherapy (Tokyo)

Journal Code:L0028A

ISSN:0914-2223

VOL.17;NO.1;PAGE.33-38(2003)

Figure&Table&Reference;FIG.3, TBL.4, REF.9

Pub. Country;Japan

Language;Japanese

Abstract;The antitumor effect of extracfs obtained from Agaricus blazei was compared with that of extracts obtained from Coriolus, PSK. BALB/c mice received simultaneous intradermal injections of Meth-A tumor cells in both the right primary tumor (2*106 cells) and left metastatic tumor (2*105 cells), and were then injected with 5 mg of extracts in the right tumor on days 3, 4 and 5 (double grafted tumor system). PSK induced cure of not only the primary solid tumor but also the metastatic, distant tumor. Agaricus extracts induced regression of the primary tumor and inhibition of growth of the metastatic tumor. The tumor cells on day 7 from extract-treated primary tumors and from metastatic tumors were cultured for 24 hours and their culture supernatants were assayed for macrophage chemotactic activity (MCF). Significant MCF activity was detected in PSK-treated primary and metastatic tumor tissue and in Agaricus extract-treated metastatic tumor tissue. Immunosuppressive acidic protein (IAP) was found to be produced by activated macrophages. IAP in serum was increased transiently soon after intradermal injection of both extracts. The physicochemical analysis showed that both extracts were protein (17-30%)-bound glucan. These results indicate that Agaricus preparation has a direct cytotoxic effect on primary tumor and PSK induced a sequential antitumor immune mechanism on primary and metastatic tumors. (author abst.)

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