A Case of Acute Lung Injury After Nephrectomy Involving Systemic Inflammatory Response Syndrome.

Accession number;03A0169398
Title;A Case of Acute Lung Injury After Nephrectomy Involving Systemic Inflammatory Response Syndrome.
Author; HIDA SEIJI (Niigata Univ., Graduate School, JPN) OHASHI SATOMI (Niigata Univ., Graduate School, JPN) HONDA TADAYUKI (Niigata Univ., Graduate School, JPN) ENDO HIROSHI (Niigata Univ., Graduate School, JPN) KOMURA NOBORU (Niigata Univ., Medical Hospital, JPN) YAMAMOTO SATOSHI (Niigata Univ., Medical Hospital, JPN) KAZAMA JUN'ICHIRO (Niigata Univ., Medical Hospital, JPN)
Journal Title;Prog Med
Journal Code:F0664B
ISSN:0287-3648
VOL.23;NO.1;PAGE.486-489(2003)
Figure&Table&Reference;FIG.3, REF.2
Pub. Country;Japan
Language;Japanese
Abstract;We present a case of acute lung injury (ALI) after nephrectomy involving systemic inflammatory response syndrome (SIRS). A 61-year-old female was admitted to a hospital due to hypoxia and high fever on September 25. She was treated with oxygen therapy, antibiotics, and diuretics. Hipoxia and high fever persisted and gram negative rod was cultured in her blood. She was transferred to ICU and mechanically ventilated on September 27. She was discharged from ICU on the eighth day, but high fever persisted. An abdominal CT showed Lt. renal abcess. Lt. nephrectomy was done and she was admitted to ICU on October 24. She was treated with assisted ventilation and systemic antibiotics. Hypoxia and fever progressed gradually. A chest X ray showed diffuse infiltration and her condition met SIRS criteria on POD 1. SIRS was suspected as underlying cause of ALI, thus neutrophil elastase inhibitor (ELASPOL) was systemically administered. Thereafter she recovered from ALI and her condition gradually improved. It seemed that a neutrophil elastase had a major role of ALI in this case because the improvement of hypoxia corresponded to the decline in plasma concentrations of elastase. (author abst.)