Mechanical Properties of Xenograft Used for a Scaffold for Regeneration of Blood Vessels.
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Accession number;03A0197420
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| Title;Mechanical Properties of Xenograft Used for a Scaffold for Regeneration of Blood Vessels. |
| Author;
NOMURA SHUGO
(Kyoto Univ., Graduate School of Engineering, JPN)
TAKIGAWA TOSHIKAZU
(Kyoto Univ., Graduate School of Engineering, JPN)
MASUDA TOSHIRO
(Kyoto Univ., Graduate School of Engineering, JPN)
TAMURA NOBUSHIGE
(Kyoto Univ., Inst. Frontier Medical Sci., JPN)
NAKAMURA TATSUO
(Kyoto Univ., Inst. Frontier Medical Sci., JPN)
SHIMIZU YASUHIKO
(Kyoto Univ., Inst. Frontier Medical Sci., JPN)
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Journal Title;Journal of the Society of Materials Science, Japan
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Journal Code:F0385A
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ISSN:0514-5163
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VOL.52;NO.3;PAGE.309-313(2003)
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| Figure&Table&Reference;FIG.6, REF.23 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To develop small-diameter vascular grafts with high anti-thrombogenicity and the ability to grow, we prepared heparinized acellular matrices (HEPARINs) made from detergent-treated porcine carotid arteries. In this study, the mechanical properties of HEPARIN as well as the acellular matrix before heparinization (ACM) were investigated under uniaxial and biaxial deformation. The values of the initial Young's Modulus (E0) and tangent Modulus (Et) obtained by uniaxial elongation for the ACM were almost identical to those for a fresh porcine carotid artery (FRESH), but HEPARIN showed higher values than FRESH for the two mechanical parameters. The pressure at burst for ACM estimated by biaxial deformation was lower than the other samples, but was still much higher than that of normal blood pressure. It was shown that HEPARIN is one of the promising materials as a scaffold for regeneration of blood vessels as long as mechanical properties are concerned. (author abst.) |
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