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Accession number;03A0158566
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| Title;Translation arrest and its involvement in protein translocaiton across membranes. |
| Author;
NAKATOGAWA HITOSHI
(Kyodai Uirusuken Kozokeiseigakubun'ya)
ITO KOREAKI
(Kyodai Uirusuken Kozokeiseigakubun'ya)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.4;PAGE.338-345(2003)
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| Figure&Table&Reference;FIG.5, REF.41 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A certain kind of proteins distinguishes cells from the outside world, and is transported intracellularly by crossing the membranes formed for intracellular organelles. The transmembrane process of these proteins are tightly coupled with translation. A signal recognition particle(SRP) of an RNA-protein complex works on the ribosome which has initiated translation of a precursor protein in need to be translocated through membranes, once arrests the translational elongation, and is guided to the protein transmembranous device existing in the membrane of endoplasmic reticulum. When the translation is resumed, newly generated proteins are put on secretion pathways through the membranes. It has recently been proven that translation arrest is also utilized for expression control of factors involved with translocation of proteins through membranes. For translation arrest, In various forms, RNA molecules are involved in translation arrest. |
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