Translational regulation in stress response.
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Accession number;03A0158570
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| Title;Translational regulation in stress response. |
| Author;
HOSODA AKIRA
(Nara Inst. Sci. and Technol., Res. and Education Center for Genetic Information, JPN)
IWAWAKI TAKAO
(Nara Inst. Sci. and Technol., Res. and Education Center for Genetic Information, JPN)
KONO KENJI
(Nara Inst. Sci. and Technol., Res. and Education Center for Genetic Information, JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.4;PAGE.375-381(2003)
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| Figure&Table&Reference;FIG.7, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Being exposed to stresses, cells intend to avoid them by controlling both transcription and translation. As most of stresses intracellularly produce abnormally structured proteins, cells slow down translation rate of whole proteins to prevent from accumulating abnormal proteins. In eukaryotic cells the decrease of translation rate is generated by phosphorylation of eIF-2.ALPHA., a translation initiation factor. In animal cells, 4 kinds of eIF-2.ALPHA. kinases are known so far. Apart from this, it has recently been found a pathway of ihibiting protein synthesis by excising 28S rRNA. |
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