Fragile X syndrome, a disease caused by defects in an RNA-binding protein.
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Accession number;03A0158583
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| Title;Fragile X syndrome, a disease caused by defects in an RNA-binding protein. |
| Author;
SHIOMI MIKIKO
(Univ. Tokushima, Inst. Genome Res., JPN)
SHIOMI HARUHIKO
(Univ. Tokushima, Inst. Genome Res., JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.4;PAGE.480-486(2003)
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| Figure&Table&Reference;FIG.3, REF.38 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Drosophila's homologous gene product(dFMR1) to causative gene product for fragile X syndrome with mental retardation symptom (FMR1) interacts specifically with RNAi factor, ribosomal proteins, and miRNA. As FMR1 is an RNA-binding protein, it has been considered to be involved in translation control. Thecontrol mechanism of translation is indicated to be involved with RNAi factor/miRNA.Authors judge that it is possibile RNAi/miRNA-related factors to be involved in intracelebral expression network of action from the results gained by genetic analyses. |
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