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Accession number;03A0158589
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| Title;Molecular biology of SMA (spinal muscular atrophy). |
| Author;
KATAOKA NAOYUKI
(Kyodai Uirusuken Idenshidotaichosetsukenkyubumon Johokobunshikagakukenkyubun'ya)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.4;PAGE.524-531(2003)
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| Figure&Table&Reference;FIG.3, REF.43 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Spinal muscular atrophy (SMA) is caused by amyotrophia brought about by lesions of motor cells, and is an autosomal recessive heredopathy with progressive muscle force lowering. SMA's causative gene has recently been isolated, and named Survival of Motor Neurons (SMN). SMN exists intracellularly by forming multiple complexes with proteins and is called Gemin. Since many substrates associating to SMN complexes exist in ribonucleoprotein complexes(RNPs), SMN may have diverse functions in relation to intracellular RNP biosynthesis. |
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