RNA in drug development.
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Accession number;03A0158591
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| Title;RNA in drug development. |
| Author;
KOZU TOMOKO
(Saitama Cancer Center, JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.4;PAGE.540-548(2003)
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| Figure&Table&Reference;FIG.9, REF.25 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;RNA is a biological material with major and various functions in vivo. RNA molecules with new functions can be created by artificial evolution method (SELEX). RNA drug discoveries are becoming popular to apply various functions of RNA for diagnoses and disease treatments. This article introduces ribozymes, double stranded RNAs, and aptamers, which are used for gene knockdown by using functional RNAs, RNA repair, and modification of protein functions, their mechanisms, and present states of drug development. It also describes RNA biosensors which are recently developing as tools. |
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