Management of High LDL-Cholesterol Level Observed in Life-style Related Diseases.
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Accession number;03A0169311
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| Title;Management of High LDL-Cholesterol Level Observed in Life-style Related Diseases. |
| Author;
KUDO MIKIKO
(Teikyo Univ., Sch. of Med.)
TERAMOTO TAMIO
(Teikyo Univ., Sch. of Med.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.1;PAGE.19-24(2003)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The relationship between relative risk of coronary heart disease (CHD) and the serum levels of cholesterol, LDL-cholesterol, has been established in Caucasian countries as well as in Japan. Many large-scale prevention trials have been published in Caucasian countries, suggesting that decrease in LDL-C leads to significant reduction of CHD in both primary and secondary prevention studies. Recently, Heart Protection Study (HPS) has shown that reduction of LDL-C leads to prevention of cardiovascular as well as cerebrovascular diseases and total death in high-risk subjects even in the subjects with average LDL-C level. The Japanese prevention studies such as KLIS and PATE and large-scale cohort studies such as J-LIT and Hisayama studies have been published and shown that reduction of LDL-C results in prevention of CHD. On the basis of these evidences, JAS guideline has been published for the management of hyperlipidemia in 1997 and has been renewed for the prevention of atherosclerotic diseases in 2002. In the new guideline, the risk factors other than LDL-C are also emphasized and the treatment goals of LDL-C are stratified according to the risk level. To achieve the treatment goal life style modification is most emphasized in the new guideline. (author abst.) |
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