Life Style-Related Disease. Hypoalphalipoproteinemia.
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Accession number;03A0169312
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| Title;Life Style-Related Disease. Hypoalphalipoproteinemia. |
| Author;
SAKAI NAOHIKO
(Osaka Univ., Graduate School of Medicine, JPN)
YAMASHITA SHIZUYA
(Osaka Univ., Graduate School of Medicine, JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.1;PAGE.25-30(2003)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Though the pathogenesis of atherosclerosis is complicated, substantial efforts have been made to identify and treat independent risk factors and to prevent atherosclerotic disease. Recently, the "multiple risk factor syndrome (MRFS)", in which multiple risks, including dyslipidemia, glucose intolerance, and hypertension, are clustered in each individual, has been recognized as a common basis of atherosclerotic disease in the industrialized countries. Changes in Japanese life style, such as high dietary intake, low physical activity and smoking habit, cause MRFS through accumulation of intra-abdominal visceral fat (VF). Hypoalphalipoproteinemia (HDL-C < 40 mg/dL) is one of the most common dyslipidemia observed in subjects with VF accumulation, and links these subjects partly to the occurrence or development of atherosclerotic disease. Accelerated production and secretion of apo B-containing lipoproteins in the liver, and delayed catabolism of TG-rich lipoproteins in the muscle and adipose tissue caused by insulin resistance play key roles in this type of dyslipidemia. It should be stressed that non-drug therapy by correction of the life style must be tried before the use of drugs to treat dyslipidemia in the subjects with VF accumulation. (author abst.) |
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