Obesity and Insulin Resistance.
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Accession number;03A0169314
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| Title;Obesity and Insulin Resistance. |
| Author;
INUKAI KOICHI
(Saitama Medical School, JPN)
AWATA TAKUYA
(Saitama Medical School, JPN)
KATAYAMA SHIGEHIRO
(Saitama Medical School, JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.1;PAGE.35-39(2003)
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| Figure&Table&Reference;FIG.3, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Type 2 diabetes is characterized by insulin resistance of peripheral tissues such as hepatic, muscle, and adipose tissues. Although excess adipose tissue in obesity is associated with insulin resistance and type 2 diabetes, the connection between insulin resistance and obesity has been obscure. Recent studies have indicated that adipose tissue is, in addition to being a lipid storage site, an endocrine organ producing hormones, cytokines and other substances. These substances were designated adipocytokines. Among them, TNF alpha, resistin and PAI-1 have been shown to cause obesity-induced insulin resistance and thrombosis, while leptin and adiponectin have been demonstrated to have important roles in glucose and lipid homeostasis. In particular, adiponectin, which is an insulin-sensitizing hormone, is expected to be useful in the treatment of diabetes and atherosclerosis. (author abst.) |
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