Vascular Disorders and Cognitive Dysfunction Associated with Homocysteinemia.
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Accession number;03A0169315
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| Title;Vascular Disorders and Cognitive Dysfunction Associated with Homocysteinemia. |
| Author;
TAKAO MASAKI
(Keio Univ., School of Medicine, JPN)
TANAHASHI NORIO
(Keio Univ., School of Medicine, JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.1;PAGE.41-46(2003)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.31 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Homocysteine is the sulfur containing amino acid that is formed from the methionine. Hyperhomocysteinemia is characterized by the elevation of the plasma homocysteine level more than 15 .MU.mol/L. Recent several studies indicated that the oxidative metabolism of homocysteine to homocysteine might cause damage to the vascular endothelial cells and proliferation of the vascular smooth muscle cells. In addition to the several genetic diseases, hyperhomocysteinemia is seen in several conditions such as smoking, pernicious anemia, renal failure, hypothyroidism, carcinoma as well as using phenytoin, theophylline and methotrexate. Epidemiological analyses revealed that hyperhomocysteinemia may be associated with coronary artery disease, cerebrovascular disease, deep vein thrombosis as well as cognitive dysfunction. In some instances, the vitamin supplementation decreases or normalizes the plasma homocysteine concentration. Further prospective and well-designed studies may warrant the treatment of hyperhomocysteinemia seen in the several conditions. (author abst.) |
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