Regulation of Mouse Retinol Dehydrogenases and Retinal Dehydrogenases in Hepatocyte Differentiation.
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Accession number;03A0182088
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| Title;Regulation of Mouse Retinol Dehydrogenases and Retinal Dehydrogenases in Hepatocyte Differentiation. |
| Author;
TOMITA K
(Keio Univ. School Of Medicine, Tokyo, Jpn)
AZUMA T
(Keio Univ. School Of Medicine, Tokyo, Jpn)
INOKUCHI S
(Keio Univ. School Of Medicine, Tokyo, Jpn)
KITAMURA N
(Keio Univ. School Of Medicine, Tokyo, Jpn)
NISHIMURA T
(Keio Univ. School Of Medicine, Tokyo, Jpn)
KATO S
(Keio Univ. School Of Medicine, Tokyo, Jpn)
ISHII H
(Keio Univ. School Of Medicine, Tokyo, Jpn)
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Journal Title;Japanese Journal of Alcohol Studies & Drug Dependence
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Journal Code:G0193B
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ISSN:1341-8963
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VOL.38;NO.1;PAGE.46-57(2003)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.17 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Retinoic acid (RA) is produced via two sequential reactions of retinol dehydrogenases (RDHs) and retinal dehydrogenases (RALDHs). We found that primary cultured mouse hepatocytes on a single collagen gel gradually lost hepatocyte specific morphology, and that another collagen gel overlay remarkably recovered it. The levels of albumin and liver-dominant expressed RDHs expression in hepatocytes paralleled their morphological change, decreased during single collagen gel culture, and were up-regulated by sequential collagen overlay. Quite similar to the expression changes, albumin and those RDHs' mRNA expression levels increased along with liver differentiation during pre- and postnatal liver development. Our data supports that all-trans and 9-cis RA, catalyzed by the RDHs, indeed play an important role in liver differentiation and regeneration. (author abst.) |
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