The Role of Autonomic Nervous system in Bronchial Asthma and Allergy. From Aspects of Basic Research.

Accession number;03A0196670
Title;The Role of Autonomic Nervous system in Bronchial Asthma and Allergy. From Aspects of Basic Research.
Author; NAGATA SHOJI (Univ. Occupational and Environmental Health, Inst. Industrial Ecological Sci., JPN)
Journal Title;Prog Med
Journal Code:F0664B
ISSN:0287-3648
VOL.23;NO.2;PAGE.567-571(2003)
Figure&Table&Reference;FIG.2, TBL.2, REF.7
Pub. Country;Japan
Language;Japanese
Abstract;Bronchial asthma is characterized by 3 features; 1) bronchial hypersensitivity, 2) diffuse bronchial obstruction and 3) chronic inflammation induced by the T-lymphocytes, mast cells and eosinophils. Autonomic nervous system (ANS) is related to all of these 3 features. Recent advances m the field of neurochemistry revealed the involvement of sensory neuropeptides to the inflammation in the airway. The role of ANS and sensory nerve in inflammation and keeping homeostasis of airway, parasympathetic involvement in suggested airway constriction and conditioned asthmatic attack, increased tonus of sympathetic nerve after anterior hypothalamic lesioning which suppress the immediate and late allergic reaction, are reviewed. (author abst.)