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Accession number;03A0196693
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| Title;Combination with Angiotensin-Converting Enzyme(ACE) Inhibitor(imidapril) and Angiotensin-receptor. Antagonist (ATA)(losartan) Provides a Greater Renoprotective Effect than ATA Alone in Type-2 Diabetic Patients with Microalbuminuria. |
| Author;
OGAWA SUSUMU
(Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka)
TAKEUCHI KAZUHISA
(Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka)
KATO TARO
(Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka)
ISHIZUKA TSUNEO
(Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka)
ITO SADAYOSHI
(Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.2;PAGE.713-717(2003)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Aim; To investigate the difference in a renoprotective effect between losartan monotherapy and combination therapy with losartan and imidapril in type 2 diabetic outpatients with microalbuminuria. Methods: Ten subjects treated with losartan (50 mg daily) were randomly divided to two groups: further treatment with 100 mg of losartan (Los, n = 5); 50 mg of losartan combined with 5 mg of imidapril (Los + Imp, n = 5), and the treatments were continued for one year. The renoprotective efficacy was assessed by a change in urinary albumin-to-creatinin ratio (ACR). Results: There was a significant decrease in ACR in Los + Imp than in Los (Los + Imp, -60%, Los, -40%, p = 00437). Conclusions: Combination of imidapril in losartan treatment would be more effective than llosartan monotherapy. (author abst.) |
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