Relationship of Helicobacter heilmannii Infection and Parietal Cell.
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Accession number;03A0250900
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| Title;Relationship of Helicobacter heilmannii Infection and Parietal Cell. |
| Author;
NAKAMURA MASAHIKO
(Kitasato Inst. Res. Division, JPN)
MATSUI HIDENORI
(Kitasatodai Kitasatoseimeikaken)
AKIBA YASUTADA
(Keio Univ.)
NISHIKAWA KAORI
(Kyorin Univ., Fac. of Med.)
TAKAHASHI SHIN'ICHI
(Kyorin Univ., Fac. of Med.)
ISHII HIROMASA
(Keio Univ.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.3;PAGE.822-825(2003)
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| Figure&Table&Reference;FIG.1, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Helicobacter heilmannii (HHLO) infection has recently attracted attention as a zoonosis, while its clinical significance remains to he clarified. Thus, the present study was undertaken to clarify the localization of HHLO in the mouse infected with HHLO for one year and the alteration of the gastric glandular cells. The localization of HHLO was investigated by the immunohistochemistry using a monoclonal antibody against Helicobacter pylori and H+, K+-ATPase and electron microscopy. As a result, HHLO bacilli were localized in the mucus layer just adjacent to the surface epithelial cells and in the middle portion of the gastric glandular lumen. By the electron microscopic observation, some of the bacilli were localized in the intracellular canaliculi of the parietal cells and some of these infected parietal cell fell into necrosis. By the immunohistochemistry of H+ K+-ATPase counterstained with alexa-phalloidin, some of the parietal cells were shown to have lost its immunoreactivity. In conclusion, HHLO infection was shown to bring about the necrosis of the parietal cell, suggesting its interaction with gastric mucosal atrophy. (author abst.) |
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