Changes in Gastric Mucosal Blood Flow Following Administration of Geranylgeranylacetone in an Animal Model of Helicobacter pylori Infection.
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Accession number;03A0250902
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| Title;Changes in Gastric Mucosal Blood Flow Following Administration of Geranylgeranylacetone in an Animal Model of Helicobacter pylori Infection. |
| Author;
MIYAZAKI MITSUJISEBASUCHAN
(Kumamoto Univ., School of Medicine, JPN)
MATSUDA MIMIAN
(Kumamoto Univ., School of Medicine, JPN)
MURATA HIROSHI
(Akasakaichokurinikku)
MISUMI ATSUNOBU
(Kyushugankenkyukai)
MURAKAMI AKITOSHI
(National Sanatorium Kikuchi Keifuen Hospital, JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.3;PAGE.829-833(2003)
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| Figure&Table&Reference;FIG.4, REF.37 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In recent years, Helicobacter pylori (H. pylori) infection has become known as causative factor in gastric mucosal conditions including gastritis, gastric ulcers, gastric cancer and malignant lymphoma. In this study, using Mongolian gerbils we produced 2 groups, a group 72 weeks post infection with H. pylori (H. pylori group) and a group 76 weeks old not infected with H. pylori (Control group). The H. pylori group were administered geranylgeranylacetone (GGA) for 14 days, and gastric mucosal blood flow was measured under ether anesthesia on day 1 (GGAD1) and day 14 (GGAD14) of administration. The control group were raised under normal conditions, and underwent the same investigations. Gastric mucosal blood flow differed significantly (p<0.03) between GGAD1 at 11.5.+-.0.7 mL/min/100g and GGAD14 at 18.8.+-.5.9. No significant difference was seen in the control group, however, between blood flow on the first day (CD1) at 27.5.+-.1.9 and the final day (CD14) at 25.6.+-.2.4. Significant differences were also seen between GGAD1 and CD1 (p<0.05). Gastric mucosal blood flow was significantly reduced in the group infected with H. pylori, but improvement was seen with the administration of GGA. This suggests that GGA is effective in improving gastric mucosal blood flow reduced by H. pylori infection. (author abst.) |
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