Effects of Advanced Glycation End-products (AGEs) and Atherosclerosis on Gastric Mucosal Lesion in Patients on Maintenance Hemodialysis (HD).
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Accession number;03A0250903
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| Title;Effects of Advanced Glycation End-products (AGEs) and Atherosclerosis on Gastric Mucosal Lesion in Patients on Maintenance Hemodialysis (HD). |
| Author;
IWAI ATSUHIRO
(Natl. Def. Med. Coll.)
ITO KAZURO
(Natl. Def. Med. Coll.)
MIURA SOICHIRO
(Natl. Def. Med. Coll.)
NAKAMURA OSAMU
(Kisenbyoin Naika)
SUDO YUJI
(Kisenbyoin Naika)
KOBAYASHI MAKIO
(Tokyo Women's Med. Coll.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.3;PAGE.834-838(2003)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;BACKGROUND: Patients with end-stage renal disease (ESRD) display very high levels of advanced glycation end-products (AGEs). The aim of this study was to assess effects of extent AGEs and atherosclerosis on gastric mucosal lesion. METHODS: Upper endoscopy and plain chest radiographs were performed in 15 non-diabetic and 5 diabetic ESRD patients on maintenance hemodialysis. Gastric biopsies were taken from these patients and we examined the immunohistochemical distribution and localization of AGEs (6 D12, pentosidine), 4 NHE (4-Hydroxy 2,3-(E)-noneal), 8-OHdG (8-OH-2-deoxyguanosine). The degree of atherosclerosis was scored by the presence or absence of aortic arch calcification and the kinking of thoracic aorta. RESULTS: (1) Expression of 4 NHE and 8-OHdG in gastric mucosa decreased in patients using the hemodialysis with vitamin E-coated dialysis filters. (2) Significant difference was found between atherosclerosis positive group and negative group in both neutrophil infiltration in gastric body mucosa and 8-OHdG in gastric antral endothelial cells. (3) Age, LDL-cholesterol, neutrophil infiltration in gastric body mucosa and antral 8-OHdG expression were independent factors to predict the degree of atherosclerosis. CONCLUSION: Complex interaction among AGEs, 8-OHdG, ischemic-reperfusion during hemodialysis and atherosclerosis might be critical to gastric mucosal lesion in patients on maintenance hemodialysis. (author abst.) |
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