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Accession number;03A0250908
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| Title;Dietary Nitrate Generates Potentially Mutagenic Concentrations of Nitric Oxide at the Gastroesophageal Junction. |
| Author;
IIJIMA KATSUNORI
(Tohoku Univ., Sch. of Med.)
SHIMOSEGAWA TOORU
(Tohoku Univ., Sch. of Med.)
MCCOLL K E L
(Univ. Dep. Medicine And Therapeutics, Glasgow, Gbr)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.3;PAGE.854-856(2003)
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| Figure&Table&Reference;FIG.2, REF.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;When saliva is swallowed, the acidic gastric juice reduces the nitrite present in the saliva to nitric oxide. The aim of this study was to examine the anatomic distribution of nitric oxide generation within the lumen of the upper gastrointestinal tract after ingesting nitrate equivalent to that in salad portion. Methods: Using custom-made sensors, the dissolved luminal nitric oxide concentration and pH were measured at 1-cm increments for 2 minutes throughout the length of the stomach and distal esophagus in 15 Helicobacter pylori-negative healthy volunteers with and without ingestion of 2 mmol potassium nitrate. Results: The mean nitric oxide concentration over the 1-cm segment immediately distal to the gastroesophageal pH step-up after nitrate was 7.5 mmol/L and was significantly higher than at all other sites. Nitric oxide concentrations greater than 50 mmol/L were observed at the precise location where neutral esophageal pH fell to acidic gastric pH. Conclusions: Luminal generation of nitric oxide from dietary nitrate via salivary nitrate is maximal at the gastroesophageal junction and cardia. The high concentrations of nitric oxide generated may contribute to the high incidence of mutagenesis and neoplasia at this site. (author abst.) |
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