Life Style Related Disease (Insulin Resistance Related Disease) and Colon Polyp.
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Accession number;03A0250911
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| Title;Life Style Related Disease (Insulin Resistance Related Disease) and Colon Polyp. |
| Author;
YOSHIDA ISAO
(Kanazawa Univ., Hospital, JPN)
SUZUKI AYAKO
(Kanazawa Univ., Hospital, JPN)
SAWADA TAKESHI
(Kanazawa Univ., Hospital, JPN)
MUTO AYAKO
(Kanazawa Univ., Hospital, JPN)
MATANO YUTAKA
(Kanazawa Univ., Hospital, JPN)
OKADA TOSHIHIDE
(Kanazawa Univ., Hospital, JPN)
MASUNAGA TAKAHARU
(Kanazawa Univ., Hospital, JPN)
MABUCHI HIROSHI
(Kanazawa Univ., Graduate School of Medical Sci., JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.3;PAGE.871-875(2003)
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| Figure&Table&Reference;FIG.2, TBL.4, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Several reports show increased incidence of colorectal cancer (CRC) in acromegaly. Previously we showed a higher prevalence of hyperplastic polyps (HPs) as well as CRCs in acromegaly. Considering that both Insulin-like growth factor (IGF) and insulin may promote proliferation of colorectal epithelium through stimulating IGF-1 receptors, we hypothesize that hyperinsulinemia may be related to the incidence of HPs, and subsequently the risk of CRC as seen in acromegaly. In this study, we assessed the relation between insulin resistance (IR)-related diseases (IRRDs) and the prevalence of colorectal polyps. The IR group was associated with higher prevalence of HPs (p<0.0001), especially solitary HPs located in the distal colon (p<0.01). More than 3 solitary HPs in the distal colon were associated with a tendency towards high prevalence of serrated adenoma. Serrated adenomas tended to coexist with advanced adenomatous polyps. The prevalence of HPs was significantly associated with IRRDs. Considering these results in addition to our previous results in acromegaly, we believe hyperinsulinemia may be a predisposing factor of CRC through hyperplasia-adenoma-carcinoma sequence. (author abst.) |
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