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Accession number;03A0271456
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| Title;Alternative splicing of CaV2 genes and their functional significance. |
| Author;
KANEKO SHUJI
(Kyoto Univ., Graduate School of Pharmaceutical Sciences, JPN)
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Journal Title;Folia Pharmacologica Japonica
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Journal Code:G0740A
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ISSN:0015-5691
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VOL.121;NO.4;PAGE.233-240(2003)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.41 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Alternative splicing is one of the most pharmacologically and physiologically significant mechanisms for the functional diversity of the mammalian genomes. Here I review recent results on the diversity of the CaV2 subclass of voltage-dependent Ca2+ channel gene in neurons. Although the entire picture of alternative splicing is not yet understood, emerging evidences suggest the CaV2 isoforms permit optimization of Ca2+ signaling in different regions of the brain with specific pharmacological ligands. (author abst.) |
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