Inositol 1,4,5 trisphosphate (IP3) receptor.
|
Accession number;03A0271457
|
| Title;Inositol 1,4,5 trisphosphate (IP3) receptor. |
| Author;
MIKOSHIBA KATSUHIKO
(Univ. Tokyo, Inst. Medical Sci., JPN)
|
Journal Title;Folia Pharmacologica Japonica
|
Journal Code:G0740A
|
ISSN:0015-5691
|
|
VOL.121;NO.4;PAGE.241-253(2003)
|
| Figure&Table&Reference;FIG.9, TBL.1, REF.44 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The intensive molecular and biochemical study of IP3R has made great progress in elucidating the following unique properties of IP3R: 1) IP3 dependent Ca2+ release is quantal in nature; 2) IP3R allosterically and dynamically changes its form; 3) IP3R is functional even though it is fragemented by proteases into several pieces;4) IP3R forms a functional association with a variety of molecules inside the cell, and with the channels on the plasma membrane; 5) the extremely high IP3 binding affinity(500-1000 times higher than the original IP3R)sequence in the IP3 binding region is covered with a suppressor sequence at the Nterminal. In parallel with these biochemical studies, studies on the role of IP3R during development have greatly advanced. Since IP3R was identified as a developmentally regulated phospho-glycoprotein, the Ca2+ channel P400, it has diverse but essential functions in development and normal cell function. (author abst.) |
|
|
|
Related Articles;
|
|
|
