Cases of Mother and Daughter with Type 1 Diabetes Mellitus, Rheumatoid Arthritis, and Autoimmune Thyroid Disease.
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Accession number;03A0177720
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| Title;Cases of Mother and Daughter with Type 1 Diabetes Mellitus, Rheumatoid Arthritis, and Autoimmune Thyroid Disease. |
| Author;
YAMAMOTO SHIGEKI
(Mitsubishikagakubyoin Naika)
FUJIMOTO HIROSHI
(Mitsubishikagakubyoin Naika)
MORIMOTO ISAO
(Inoebyoin Naika)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.46;NO.2;PAGE.139-144(2003)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We report the cases of a mother and daughter with type 1 diabetes mellitus (DM), rheumatoid arthritis (RA) and autoimmune thyroid disease (AITD). Case 1: A 60-year-old mother with RA at age 40 was diagnosed with type 1 DM at age 50 due to low 8 .MU.g/day urinary C-peptide (CPR) and a positive test for glutamic acid decarboxylase antibody (GADAb). She had diffuse goiter and her autoimmune thyroid antibodies were positive. She was diagnosed with chronic thyroiditis. Case 2: The woman's 33-year-old daughter was diagnosed with Graves' disease at age 8, and took antithyroid drugs. She had euthyroid function due to medication but had positive TSH receptor antibody (TRAb). She was diagnosed with gestational DM at age 26 and treated with insulin. She was later diagnosed with type 1 DM due to undetectable urine CPR and positive GADAb. She was diagnosed with RA at age 30. Few familial cases combining type 1 DM, RA, and AITD have been reported. These diseases may be associated with DR 4-DQB 1*0302 antigen, which was observed in both cases. (author abst.) |
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