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Accession number;03A0318143
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| Title;Studies on the Syntheses of the Hypermodified Nucleosides of Phenylalanine Transfer Ribonucleic Acids |
| Author;
ITAYA TAISUKE
(Kanazawa Univ., Faculty of Pharmaceutical Sci., JPN)
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Journal Title;Journal of the Pharmaceutical Society of Japan
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Journal Code:F0508A
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ISSN:0031-6903
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VOL.123;NO.5;PAGE.267-283(2003)
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| Figure&Table&Reference;FIG.19, REF.60 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;This review highlights the first total synthesis of (.ALPHA.S,.BETA.S)-.BETA.-hydroxywybutosine, the identity of which was established with fluorescent nucleoside isolated from rat liver tRNAPhe. Three general prerequisites for the synthesis of the target are emphasized: construction of new 9-.BETA.-D-ribofuranosyl-3-methylpurines; the first syntheses of optically active .GAMMA.-aryl-.ALPHA.,.BETA.-unsaturated amino acids; and a new method for hydrogenolysis of glycols through their cyclic carbonates to give the .GAMMA.-aryl-.BETA.-hydroxy amino acid derivatives. The mechanism for the formation of cyclic carbonates from reactions of glycols with (COCl)2 and highly selective preparation of the cyclic oxalates are also described. (author abst.) |
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