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Accession number;03A0333110
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| Title;IFN Resistance of HCV: Investigation into its Genetic Backgrounds |
| Author;
CHEN C-H
(Tokyo Med. and Dent. Univ.)
ENOMOTO NOBUYUKI
(Tokyo Med. and Dent. Univ.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.4;PAGE.1041-1045(2003)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Hepatitis C virus is a major cause of chronic hepatitis that progresses to liver cirrhosis and hepatocellular carcinoma. Only available therapy for chronic hepatitis C is the treatment based on IFN. However, genotype 1b, that is a most prevalent genotype in Japan, is interferon-resistant strain. We investigated the relation of HCV genetic structure to the response to interferon, and found the interferon sensitivity determining region (ISDR: aa.2209-2248) in NS5A of genotype 1b. NS5A reportedly inhibits the interferon induced double-stranded RNA-dependent protein kinase (PKR) which plays a key role in the antiviral and antiproliferative effects of interferon. Recent development of HCV replicon system enables us to investigate the effect of IFN/Ribavirin against HCV in vitro. (author abst.) |
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