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Accession number;03A0333111
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| Title;Impaired Response to Interferon-.ALPHA. in Dendritic Cells from Chronic Hepatitis C Patients |
| Author;
KANTO TATSUYA
(Osaka Univ., Graduate School of Medicine, JPN)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.4;PAGE.1047-1051(2003)
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| Figure&Table&Reference;FIG.5, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Dendritic cells (DC) are potent antigen-presenting cells that regulate anti-virus immune responses by interacting with other types of blood cells. NK cells and CD 4 T-cells are essential players in innate and adaptive immune reactions, respectively. Here we show that myeloid DC in chronic hepatitis C patients are impaired in the stimulation of NK cells as well as CD 4 T-cells in response to interferon-.ALPHA.. Such DC impairment in HCV-infected patients is critically involved in HCV persistence and also unresponsiveness to IFN-.ALPHA. therapy. The precise mechanisms that lead to DC dysfunction in HCV infection need to be clarified to establish anti HCV immunotherapy. (author abst.) |
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