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Accession number;03A0333112
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| Title;Evaluation of Risk for Hepatocarcinogenesis by Mitochondrial DNA Analysis |
| Author;
NISHIKAWA MANABU
(Osakashidai Daigakuin'igakukenkyuka Bunshibyotaigaku)
INOUE MASAYASU
(Osakashidai Daigakuin'igakukenkyuka Bunshibyotaigaku)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.4;PAGE.1053-1057(2003)
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| Figure&Table&Reference;FIG.5, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Unlike other types of cancer, hepatocellular carcinoma (HCC) is usually preceded by chronic inflammation by viral infection. The mutation of mitochondrial DNA (mtDNA) in hepatocarcinogenesis associated with viral infection was investigated. Compared with control liver tissue, the frequency of mtDNA mutations was markedly increased in both noncancerous and cancerous liver speciments from individuals with HCC. The accumulation of mtDNA mutations in HCC tissue was also greater than that previously described for other types of tumors. These observations suggest that the repeated destruction and regeneration of liver tissue associated with chronic viral hepatitis lead to the accumulation of mtDNA mutations. So analysis of mtDNA mutation is useful for evaluation of risk for hepatocarcinogenesis. (author abst.) |
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