Screening Method for Chronic Hepatitis C
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Accession number;03A0333115
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| Title;Screening Method for Chronic Hepatitis C |
| Author;
FUJIMOTO KENJI
(Osaka Police Hosp.)
WADA SHIGEO
(Osaka Police Hosp.)
OSHITA MASAHIDE
(Osaka Police Hosp.)
MEREN HARUYA
(Osaka Police Hosp.)
KATO MICHIO
(Osaka National Hospital, JPN)
MASUZAWA MANABU
(Osaka Police Hosp.)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.23;NO.4;PAGE.1069-1077(2003)
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| Figure&Table&Reference;FIG.6, TBL.4, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Chronic hepatitis C develops slowly over time, and liver cirrhosis and hepatocellular carcinoma are terminal stages in the natural courses of the disease. Therefore, it becomes quite essential to identify the high risk factors of hepatic carcinoma in chronic hepatitis for early detection and interruption of development of hepatocellular carcinoma. The risk of developing hepatocellu-lar carcinoma in the patients with chronic hepatitis C is reportedly associated with its hepatic fibrosis stage. Especially, the risk of developing hepatocellular carcinoma is higher in F3 and F4 stages than in F1 and F2 stages in the hepatic fibrosis stage. To determine the stage of hepatocellular fibrosis, liver biopsy is necessary, but a noninvasive screening method has to be employed to monitor its chronological course. Regarding the hematological examinations, measurements of the platelet count, serum albumin, choline esterase, hepaplastin test, total cholesterol, total bilirubin, AST, ALT, and hepatic fibrosis marker are effective. As a marker of hepatitis C virus (HCV) to detect HCV infection, the presence or absence of the HCV antibody is tested, and the amount of HCV-RNA is measured to determine the activity of HCV. The HCV genotype is measured to evaluate the sensitivity against interferon. Among the various diagnostic imaging modalities, ultrasound examination is the most effective method to evaluate chronic hepatitis. Recently, ultrasonic tissue characterization to quantitatively evaluate the tissues from the ultrasound images has been approached, and we have evaluated the tissue characterization method using the Integrated Backscatter Signal (TB) and have confirmed its effectiveness. (author abst.) |
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