Science Links Japan | Studies on 2-Hydroxyestradiol 17-Sulfate Derived from Fetoplacental Unit: The Antioxidant as a Potential Defense Substance Against Preeclampsia

Studies on 2-Hydroxyestradiol 17-Sulfate Derived from Fetoplacental Unit: The Antioxidant as a Potential Defense Substance Against Preeclampsia

Accession number;03A0389547

Title;Studies on 2-Hydroxyestradiol 17-Sulfate Derived from Fetoplacental Unit: The Antioxidant as a Potential Defense Substance Against Preeclampsia

Author; TAKANASHI KAORI (Hokkaido Inst. of Pharm. Sci.)

Journal Title;Journal of the Pharmaceutical Society of Japan

Journal Code:F0508A

ISSN:0031-6903

VOL.123;NO.6;PAGE.399-411(2003)

Figure&Table&Reference;FIG.9, TBL.5, REF.51

Pub. Country;Japan

Language;Japanese

Abstract;The antioxidant 2-hydroxyestradiol 17-sulfate (2-OH-E2-17-S) was found to be present in the placenta and to prevent the onset of preeclampsia. From experiments using rats, 2-OH-E2-17-S was confirmed to be a highly functional compound with stronger antioxidant activity than .ALPHA.-tocopherol and to sustain its antioxidant activity. 2-OH-E2-17-S was confirmed to be produced in the placenta from its precursor, estradiol 17-sulfate (E2-17-S), which is derived from fetal testosterone sulfate (TS). Since the fetal adrenal gland has been shown to convert testosterone (T) into TS, the following metabolic pathway may exist during pregnancy: T.RAR.TS.RAR.E2-17-S.RAR.2-OH-E2-17-S. This fetoplacental pathway may contribute to the maintenance of healthy pregnancy. Details and the experimental outline of these discoveries are reported in this review. (author abst.)

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