The Higher Immunoreactivity to ACE (Angiotensin Converting Enzyme) in Patients with Type 2 Diabetes Mellitus than in Non-Diabetic Individuals
|
Accession number;03A0337722
|
| Title;The Higher Immunoreactivity to ACE (Angiotensin Converting Enzyme) in Patients with Type 2 Diabetes Mellitus than in Non-Diabetic Individuals |
| Author;
NISHIDA S
(Kawasaki Medical School, Okayama, Jpn)
NOHNO T
(Kawasaki Medical School, Okayama, Jpn)
HIROKAWA Y
(Kawasaki Medical School, Okayama, Jpn)
MATSUKI M
(Kawasaki Medical School, Okayama, Jpn)
TANAKA J
(Kawasaki Medical School, Okayama, Jpn)
ICHIHARA K
(Kawasaki Medical School, Okayama, Jpn)
|
Journal Title;Endocr J
|
Journal Code:F0625A
|
ISSN:0918-8959
|
|
VOL.50;NO.2;PAGE.209-213(2003)
|
| Figure&Table&Reference;TBL.5, REF.7 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In a random sample of 200 patients with type 2 diabetes mellitus, immunoreactivities to ACE (angiotensin converting enzyme) were measured by ELISA. Immunoreactivities were positive for 129 (64.5%) patients, and were positive in 30 (83.3%) out of 36 patients in the early stage of clinical diabetic nephropathy. Serum ACE activity in rabbits immunized with ACE decreased to 50% of the control level after 7 months (78.0.+-.3.8IU/L/37.DEG.C.,basal,42.0.+-.5.0 at 7 months and 33.3.+-.3.5IU/L/37.DEG.C. at 8 months,respectively). When rabbit serum containing antiACE antibodies was mixed, after heat-treatment at 56.DEG.C. for 30min, with normal human serum, the ACE activity was reduced in a concentration-dependent manner. These results suggested that anti-ACE autoantibody may be present in patients with type 2 diabetes mellitus. However, the absence of data on the epitope for the antibody does not allow any conclusion except that the immunoreactivities to ACE are higher in type 2 diabetic patients than in non-diabetic individuals. (author abst.) |
|
|
|
Related Articles;
|
|
|
