Spontaneous Cerebellar Dysplasias in BrlHan: WIST@Jcl Rats.
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Accession number;03A0376734
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| Title;Spontaneous Cerebellar Dysplasias in BrlHan: WIST@Jcl Rats. |
| Author;
KUWAMURA Y
(Tanabe Seiyaku Co., Ltd., Osaka, Jpn)
ADACHI T
(Tanabe Seiyaku Co., Ltd., Osaka, Jpn)
TAKATANI H
(Tanabe Seiyaku Co., Ltd., Osaka, Jpn)
YUASA H
(Tanabe Seiyaku Co., Ltd., Osaka, Jpn)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.52;NO.2;PAGE.165-168(2003)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Focal disturbed laminar architecture in cerebellar vermis was observed in 25 out of 100 (25%) males, and 25 out of 100 (25%) females of BrlHan: WIST@Jcl rats. The cortical molecular and granular layers were haphazardly distributed around the primary and/or secondary fissures. The stellate and basket cells positively stained with parvalbumin immunohistochemistry were observed exclusively in the separated molecular layer. Purkinje cells were found at the boundary between the molecular and the granular layers. Glial fibrillary acid protein (GFAP) immunohistochemistry revealed disarranged fibers of the Bergman glial cells. Based on the incidence of this spontaneous cerebellar lesion, it was presumed to be related to certain genetic factors of this rat strain. (author abst.) |
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