Influence of Insulin Glargine and NPH Human Insulin on QOL in Intensive Insulin Treatment for Type 1 Diabetic Patients
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Accession number;03A0402379
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| Title;Influence of Insulin Glargine and NPH Human Insulin on QOL in Intensive Insulin Treatment for Type 1 Diabetic Patients |
| Author;
ISHII HITOSHI
(Tenri Hospital)
KAWAMORI RYUZO
(Juntendo Univ., School of Medicine, JPN)
IWAMOTO YASUHIKO
(Diabetes Center, Tokyo Women's Medical Univ., JPN)
KADOWAKI TAKASHI
(Univ. Hospital, Fac. Medicine, Univ. Tokyo, JPN)
IWASAKI MANABU
(Seikei Univ., Fac. Engineering, JPN)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.19;NO.5;PAGE.483-496(2003)
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| Figure&Table&Reference;FIG.3, TBL.4, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Since strict control of blood glucose is needed for the treatment of Type 1 diabetes, self-injection of insulin is essential in addition to dietary therapy, exercise therapy, and medical therapy. However, it is of great importance that the patient thoroughly understands and is satisfied with the therapies. Currently, psychological assessment such as quality of life (QOL) has been increasingly carried out in addition to evaluation of HbA1c or complications. Insulin glargine (glargine) has been developed as an insulin preparation that compensates for basal insulin secretion: it has no definitive peaks and maintains a steady state over the day. It has been reported overseas that glargine maintains blood glucose levels in Type 1 diabetic patients in the same way as does NPH, and decreases the incidence of hypoglycemia, especially at night, better than NPH. Thanks to this profile, glargine is expected to improve the QOL of diabetic patients. The QOL of glargine and NPH users were compared in a study to investigate the efficacy and safety of the two drugs for 28 weeks in treating Type 1 diabetic patients. The total number of registered patients was 370, with 293 assigned to one or other of the preparations (145 for glargine and 148 for NPH), and 77 not assigned. Analysis was carried out on 119 in the glargine group and 120 in the NPH group whose data were available at the beginning and at the end of the study. In the Diabetes Treatment Satisfaction Questionnaire (DTSQ), a statistically significant bias toward satisfaction was seen in the glargine group. No such change was seen in the NPH group. Statistically significant changes were shown in 5 of the 6 items for treatment satisfaction in the glargine group, but only in 1 item in the NPH group. Also, in the DTSQ items related to high and low blood glucose level, a statistically significant bias toward satisfaction was shown in the glargine group.... (author abst.) |
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