Hypotensive effect of timolol and latanoprost instillation in normal-tension glaucoma.
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Accession number;03A0266051
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| Title;Hypotensive effect of timolol and latanoprost instillation in normal-tension glaucoma. |
| Author;
HASHIMOTO TAKAKO
(Jichi Medical School, Dep. Medicine, JPN)
HARA TAKESHI
(Jichi Medical School, Dep. Medicine, JPN)
TAKAHASHI YASUKO
(Jichi Medical School, Dep. Medicine, JPN)
KUBOTA SHUNSUKE
(Jichi Medical School, Dep. Medicine, JPN)
KUBOTA MIYUKI
(Jichi Medical School, Dep. Medicine, JPN)
TSURU TADAHIKO
(Jichi Medical School, Dep. Medicine, JPN)
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Journal Title;Japanese Journal of Clinical Ophthalmology
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Journal Code:Z0515B
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ISSN:0370-5579
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VOL.57;NO.3;PAGE.288-291(2003)
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| Figure&Table&Reference;TBL.2, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We evaluated the hypotensive effect of topical timolol gel and latanoprost in 33 patients of normal-tension glaucoma. By single use of timolol, the intraocular pressure(IOP) decreased from 15.0.+-.1.9mmHg to 13.3.+-.2.8mmHg after 4 weeks(p<0.01). By single use of latanoprost, the IOP decreased from 15.9.+-.1.9mmHg to 13.2.+-.2.2mmHg 4 weeks later(p<0.01). When latanoprost was added to timolol, the IOP decreased from 13.3.+-.2.8mmHg to 11.1.+-.2.5mmHg(p<0.01). When timolol was added to latanoprost, the IOP decreased from 13.2.+-.2.2mmHg to 12.0.+-.3.3mmHg(p<0.05). The success rate of decreasing the IOP by 20% or 30% from the baseline was 20.0% and 15.0% by timolol and increased to 65.0% and 40.0% by dual instillation. The success rate was 38.5% and 7.7% by latanoprost and increased to 46.2% and 30.8%. The finding shows that significant hypotensive effect can be obtained by single use of timolol or latanoprost in normal-tension glaucoma. Dual instillation induces a greater hypotensive effect. (author abst.) |
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