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Accession number;03A0287165
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| Title;Characteristic features of Leber's hereditary optic neuropathy in women |
| Author;
FUKAMI SHIN
(Inoegankabyoin)
FUJIE WAKI
(Inoegankabyoin)
WAKAKURA MASATO
(Inoegankabyoin)
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Journal Title;Japanese Journal of Clinical Ophthalmology
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Journal Code:Z0515B
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ISSN:0370-5579
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VOL.57;NO.4;PAGE.427-430(2003)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To review the characteristic features of Leber's hereditary optic neuropathy (LHON) in women. Cases: Five women were diagnosed with LHON. All the cases had mitochondrial DNA point mutation. They were aged 7, 28, 53, 66 and 66 years at the time of diagnosis. All were bilaterally involved. Findings: Three cases showed apparent differences in visual acuity between the right and left eye. Four cases showed discrepancies in visual field between right and left eye. One case aged 66 years had herpetic uveitis and another of the same age had received ethambutol before onset of LHON. Conclusions: Female patients of LHON may show differences in visual impairment between right and left eye. Visual impairments may be less severe than in males. Infection or drug administration may serve as triggers of LHON in women of advanced age. (author abst.) |
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