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Accession number;03A0313428
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| Title;Basic knowledge and clinical aspects of ketamine. Usefulness of ketamine as an analgesic; Molecular mechanism of the ketamine-induced analgesia. |
| Author;
KATO HIDEAKI
(Hoshiyakudai Yakuhindokuseigaku)
NARITA MINORU
(Hoshiyakudai Yakuhindokuseigaku)
SUZUKI TSUTOMU
(Hoshiyakudai Yakuhindokuseigaku)
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Journal Title;Pain Clinic
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Journal Code:G0739B
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ISSN:0388-4171
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VOL.24;NO.4;PAGE.477-483(2003)
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| Figure&Table&Reference;FIG.1, REF.23 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The neurogenic pain, the morphinic analgesic action, and the involvement of the NMDA(N-methyl-D-aspartic acid) receptor in the tolerance were explained with emphasis on ketamine.In the cancerous pain, many of the cases which show resistance to morphine are neurogenic pains.Clinically, for this pain the combined treatment with morphine and ketamine, a non-competitive NMDA receptor antagonist or the independent treatment is effective; the usefulness of ketamine as an analgesic adjuvant has been verified.And the repeated administration of opioid analgesics such as morphine decreases the analgesic action.The activation of protein kinase C(PKC) in the brain and spinal cord was deeply concerned in the formation of analgesic tolerance; ketamine which is the NMDA receptor antagonist indirectly controlled this PKC activity, and it was guessed that this might suppress the formation of the analgesic tolerance of morphine. |
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