Effect of Aerobic Exercise Training on the Secretion of a Novel Adipocyte-Derived Antiatherogenic Protein, Adiponectin

Accession number;03A0438029
Title;Effect of Aerobic Exercise Training on the Secretion of a Novel Adipocyte-Derived Antiatherogenic Protein, Adiponectin
Author; TAKANAMI YOSHIKAZU (Tokyo Medical College) SHIMOMITSU TERUICHI (Tokyo Medical College) KAWAI YUKARI (Tokyo Medical College) KINOSHITA FUJIHISA (Wakayama Kenko Senta) MOHIRA OSAMU (Wakayama Kenko Senta)
Journal Title;Descente Sports Science
Journal Code:L0988A
ISSN:0285-5739
VOL.24;NO.;PAGE.53-60(2003)
Figure&Table&Reference;FIG.1, TBL.4, REF.19
Pub. Country;Japan
Language;Japanese
Abstract;In this study, we verified the hypothesis that aerobic exercise training could increase adiponectin, a newly identified adipocyte-derived antiatherogenic plasma protein, in connection with the improvement of exercise tolerance and the reduction of body fat. We randomly divided the sedentary middle-aged subjects in to two groups: one that engaged in 30-60 minutes of aerobic exercise at least 3 times a week for 3 months (exercise group, n=14), and one age-matched group that underwent no modifications in physical activity (control group, n=12). Maximum oxygen uptake (VX(X=O2max), indices of body fat, serum lipids and serum adiponectin levels were analyzed bifore each experiment and after 3 months of exercise training or after 3 months of no modifications in activity (control group). Visceral fat area (VFA) and subcutaneous fat area (SFA) at the umbilical level were determined by computed tomographic scanning. VX(X=O2max) increased and body weight decreased significantly following the 3-month exercise training period. Significant reductions in VFA and SFA were observed after the exercise. Also, there was a significant increase in serum adiponectin levels following the 3-month exercise training period (5.2.+-.2.2 to 5.9.+-.2.6 .MU.g/ml; p<0.02), however, no significant change was observed in all parameters of the control group. Furthermore, the changes in serum adiponectin levels were correlated with changes in VX(X=O2max), body weight and VSA as a result of the exercise training. In conclusion, mild aerobic exercise training increases serum adiponectin levels through the improvement of exercise tolerance and the reduction of abdominal obesity. (author abst.)