Changes in QOL (SF-36) Scores of Patients with Vibration Syndrome before and after Administration of LipoPGE1 Preparation (Liple)-Focusing on Comprehensive Health-related QOL (SF-36)-
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Accession number;03A0475556
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| Title;Changes in QOL (SF-36) Scores of Patients with Vibration Syndrome before and after Administration of LipoPGE1 Preparation (Liple)-Focusing on Comprehensive Health-related QOL (SF-36)- |
| Author;
NASU YOSHIRO
(San'inrosaibyoin Seikeigeka)
FUKUHARA SHUN'ICHI
(Kyodai Igakukenkyuka Iryoekigakubun'ya)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.19;NO.6;PAGE.649-665(2003)
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| Figure&Table&Reference;FIG.2, TBL.6, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The purpose of this study were 1. To measure burden perceived by patients with vibration syndrome using both the physical and emotional health-related quality of life (QOL) 2. To examine the QOL score change before and after 2 months treatment with LipoPGE1 (Liple). Treatment with Liple in combination with other internal medicines such as anti-inflammatory agents, vasoactive agents and physiotherapy for vibration syndrome was evaluated using the before- and after-treatment results obtained using the SF-36 QOL questionnaire, and an assessment of symptoms by doctors in charge. This study was conducted from August 1999 to October 2001 at 11 facilities located within Japan, targetting patients with vibration syndrome. 1. The subjects were 84 patients with vibration syndrome given a Liple preparation intravenously to improve the subjective symptoms accompanying peripheral circulatory disturbances, and to restore peripheral circulation, peripheral nerve function and motor function. One ampoule (1ml) of the test preparation cantains lipid microspheres holding a total of 5.MU.g of alprostadil. 1-2ml of the preparation was given intravenously once daily via drip infusion at a low rate of infusion after dilution in 250ml or 500ml of normal saline for 2 weeks from the beginning of the treatment. The evaluation of the treatment was made 1-2 months after beginning treatment. 2. Health scores (SF-36, 8 sub-scales) of the patients with vibration syndrome were significantly reduced, with differences of -0.72 to -1.49 S.D. in comparison with sex- and age- matched healthy Japanese individuals (p<0.01). 3. Items with high improvement rate of 60% or more in subjective symptoms were a cold feeling in the fingers (78.1%, 25/32), numbness of fingers (68.8%, 22/32), and stiffness of the fingers (62.5%, 20/32).... (author abst.) |
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