Technetium-99m Sestamibi Imaging in Patients with Subacute Thyroiditis
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Accession number;03A0491620
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| Title;Technetium-99m Sestamibi Imaging in Patients with Subacute Thyroiditis |
| Author;
HIROMATSU Y
(Kurume Univ. School Of Medicine, Kurume, Jpn)
ISHIBASHI M
(Kurume Univ. School Of Medicine, Kurume, Jpn)
NISHIDA H
(Kurume Univ. School Of Medicine, Kurume, Jpn)
KAWAMURA S
(Kurume Univ. Hospital, Kurume, Jpn)
KAKU H
(Kurume Univ. School Of Medicine, Kurume, Jpn)
BABA K
(Kurume Univ. School Of Medicine, Kurume, Jpn)
KAIDA H
(Kurume Univ. School Of Medicine, Kurume, Jpn)
MIYAKE I
(Kurume Univ. School Of Medicine, Kurume, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.50;NO.3;PAGE.239-244(2003)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.23 |
| Pub. Country;Japan |
| Language;English |
| Abstract;To determine if subacute thyroiditis (SAT) is associated with changes in the regional perfusion of the thyroid gland, we performed Tc-99m sestamibi scans on eleven patients with SAT who had painful goiter and clinical thyrotoxicosis. Eleven patients had Tc-99m pertechnetate and Tc-99m sestamibi scintigraphy during the acute stage of SAT. The thyroid uptake ratio of sestamibi was compared with the laboratory data and color Doppler ultrasonography. Tc-99m pertechnetate scintigraphy in the thyroid was markedly reduced during the acute stage of SAT. Conversely, Tc-99m sestamibi showed diffuse increased uptake in the thyroid region, suggesting increased perfusion. On the other hand, there was near absence of vascularization in the acute phase and slight increase in the recovery phase by color Doppler ultrasonography. The clearance rate of Tc-99m sestamibi during the early phase (from 10min to 1h) was decreased in the acute stage of SAT. The sestamibi uptake ratio correlated with serum immunosuppressive acidic protein (IAP) in the acute stage of SAT and the sestamibi uptake ratio in the recovery stage of SAT was correlated with serum thyrotropin levels. Tc-99m sestamibi uptake in the early phase in the acute stage of SAT may reflect the inflammatory process associated with SAT. (author abst.) |
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