Regulation of Estrogen Receptor .ALPHA. and .BETA. Expression by Testosterone in the Rat Prostate Gland
|
Accession number;03A0491625
|
| Title;Regulation of Estrogen Receptor .ALPHA. and .BETA. Expression by Testosterone in the Rat Prostate Gland |
| Author;
ASANO K
(Hiroshima Univ., Hiroshima, Jpn)
MARUYAMA S
(Hiroshima Univ., Hiroshima, Jpn)
USUI T
(Hiroshima Univ., Hiroshima, Jpn)
FUJIMOTO N
(Hiroshima Univ., Hiroshima, Jpn)
|
Journal Title;Endocr J
|
Journal Code:F0625A
|
ISSN:0918-8959
|
|
VOL.50;NO.3;PAGE.281-287(2003)
|
| Figure&Table&Reference;FIG.3, TBL.1, REF.27 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Although ER.BETA. is known to be expressed at high levels in the rat prostate gland, its regulation is not well understood. Here we examined ER mRNA expression and the effects of testosterone administration in male rats at 1, 4 and 9 weeks of age who were castrated and/or treated with testosterone for a week, and then sacrificed. ER.ALPHA. was the major type of ER expressed in 2 week-old animals while dominant expression of ER.BETA. mRNA was apparent in older age groups. Interestingly while ER.BETA. expression was diminished and ER.ALPHA. mRNA increased in the castrated group, testosterone administration reversed this effect. A time-course study indicated that induction of ER.BETA. mRNA increased within 9hr and ER.ALPHA. decreased in 2 days after an injection (i.p.) of testosterone. Our results suggested that 1) testosterone up-regulates ER.BETA. mRNA expression while ER.ALPHA. is down-regulated; and that 2) great changes in ER.ALPHA. and .BETA. expression in the prostate gland during development from the newborn to adult may be due to the influence of testosterone. (author abst.) |
|
|
|
Related Articles;
|
|
|
