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Accession number;03A0530035
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| Title;Effect of Maxacalcitol on the Treatment of Psoriasis Vulgaris-A Comparative study of Monotherapy of Maxacalcitol Ointment and Concurrent use of Maxacalcitol and Dexamethasone Propionate Ointment- |
| Author;
TAKEMURA TSUKASA
(Shikiekimaehifuka)
ABE TOSHIHIKO
(Shikiekimaehifuka)
ARAI HIROYUKI
(Shikiekimaehifuka)
IZAKI SEIICHI
(Shikiekimaehifuka)
ENDO MIKIO
(Shikiekimaehifuka)
ONISHI YOSHIHIRO
(Shikiekimaehifuka)
OSAMURA YOZO
(Shikiekimaehifuka)
KATO TAKURO
(Shikiekimaehifuka)
KANZAKI SHUN'ICHI
(Shikiekimaehifuka)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.19;NO.7;PAGE.767-776(2003)
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| Figure&Table&Reference;FIG.4, TBL.4, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Steroid external preparations have been commonly used for topical application in the treatment of psoriasis vulgaris. Recently, some effective and new vitamin D3 analogues such as calcipotriol 50.MU.g/g, maxacalcitol 25.MU.g/g and tacalcitol 20.MU.g/g ointment have been approved. As the increase in use of these external preparations, new criteria for selection and concurrent use about steroid and active vitamin D3 derivates are needed. To investigate the appropriate concurrent use of the active vitamin D3 external preparation and steroid external preparations, a monotherapy group (maxacalcitol ointment, topical application twice daily, Group I) and a concurrent-use group (dexamethasone propionate ointment in the morning and maxacalcitol at night, Group II) were compared. Volunteers aged 16 years or older were recruited in the study on the basis of a clinical diagnosis of psoriasis vulgaris which had mild to moderate lesions. Each patients were treated twice daily in the morning and at night. The maximum amount of external use for maxacalcitol ointment was set at 5g per treatment. The study was carried out at 12 facilities affiliated with the Dermatology Treatment Association in Saitama Prefecture. Total number of the patient was 53 that consisted of 28 in group I and 25 in group II. Group I included of 15 men and 13 women and group II included 19 men and 6 women. Each age (mean .+-. S.D.) of patient for group I and II was 56.9 .+-. 16.62 and 57.2 .+-. 18.13, respectively. In a global improvement rating carried out at the end of the treatment, "cleared" was recorded by 8 subjects (29.6%) in Group I and 3 (12.0%) in Group II; "Markedly improved" was recorded by 10 (37.0%) and 10 (40.0%); "Moderately improved" was recorded by 7 (25.9%) and 9 (36.0%); Slightly improved was recorded by 2 (7.4%) and 2 (8.0%); and "Unchanged" was recorded by 0 and 1 (4.0%).... (author abst.) |
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