Effect of Telmisartan (Micardis) on Human Platelet Function.
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Accession number;03A0237823
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| Title;Effect of Telmisartan (Micardis) on Human Platelet Function. |
| Author;
UEMURA TOSHIO
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
KAKU SEIJI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
SUDO KATSUMI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
MIYATA KEIJI
(Yamanouchi Pharmaceutical Co., Ltd., JPN)
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Journal Title;Clinical Pharmacology and Therapy
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Journal Code:L1701A
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ISSN:0917-3994
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VOL.13;NO.2;PAGE.121-126(2003)
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| Figure&Table&Reference;FIG.4, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Effect of a novel AT1 receptor antagonist telmisartan on human platelet function was investigated. P-selectin expression and PAC-1 binding as markers of platelet alpha-granule secretion and activated glycoprotein (GP) IIb/IIIa, respectively, were analysed in platelets exposed to 300nM of thromboxane A2 (TXA2) analog U46619 by flow cytometry. Telmisartan significantly inhibited the P-selectin expression and GP IIb/IIIa activation at a concentration of 10.MU.M. Platelet aggregation was measured with an aggregometer, initiating the aggregation reaction either by the addition of U46619 or collagen. Telmisartan significantly inhibited both of stimulant-induced platelet aggregation at a concentration of 50.MU.M. These results indicate that telmisartan inhibits platelet activation and aggregation induced by TXA2. (author abst.) |
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