Science Links Japan | Improvement of endothelial vasodilation after balloon injury by a novel angiotensin II receptor antagonist telmisartan (Micardis) in rat carotid artery.

Improvement of endothelial vasodilation after balloon injury by a novel angiotensin II receptor antagonist telmisartan (Micardis) in rat carotid artery.

Accession number;03A0237824

Title;Improvement of endothelial vasodilation after balloon injury by a novel angiotensin II receptor antagonist telmisartan (Micardis) in rat carotid artery.

Author; FUNATSU TOSHIYUKI (Yamanouchi Pharmaceutical Co., Ltd., JPN) ARAI YUKINORI (Yamanouchi Pharmaceutical Co., Ltd., JPN) OKUTSU HIROKO (Yamanouchi Pharmaceutical Co., Ltd., JPN) KAKUTA HIROTOSHI (Yamanouchi Pharmaceutical Co., Ltd., JPN) TAKASU TOSHIYUKI (Yamanouchi Pharmaceutical Co., Ltd., JPN) SUDO KATSUMI (Yamanouchi Pharmaceutical Co., Ltd., JPN) MIYATA KEIJI (Yamanouchi Pharmaceutical Co., Ltd., JPN)

Journal Title;Clinical Pharmacology and Therapy

Journal Code:L1701A

ISSN:0917-3994

VOL.13;NO.2;PAGE.127-136(2003)

Figure&Table&Reference;FIG.3, TBL.3, REF.25

Pub. Country;Japan

Language;Japanese

Abstract;Preventive effects of telmisartan, a novel angiotensin AT1 receptor antagonist, on the neointimal hyperplasia and the endothelial dysfunction after balloon injury were examined in rat carotid artery. Two-week repeated oral administration of telmisartan at 10mg/kg/day significantly decreased both systolic and diastolic blood pressure. Telmisartan improved intimal thickening (I/M ratio) by 54%. Acetylcholine-induced vasodilation was reduced in injured arteries (maximal relaxation; 64.+-.6% in injured versus 86.+-.2% in normal, P<0.01). Telmisartan was significantly ameliorated the impairment of vascular relaxation (maximal relaxatiorn; 90.+-.5%, P<0.01). However, there was no difference in sodium nitroprusside-induced vasodilation among all groups. Telmisartan also inhibited angiotensin II-induced contractile response (maximal contraction; 62.+-.9% in injured versus 17.+-.5% in telmisartan, P<0.01). These results suggest that telmisartan prevents intimal formation and atherogenic impaired endothelial vasodilation following endothelial injury. (author abst.)

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